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Increased blood sugar Over time, some users build up a tolerance to these types of medications. Anabolic Effects Most of the studies showing anabolic effects of clenbuterol have been done on animals, but, at least one small study done on humans with chronic heart failure did show an increase in lean mass and decrease in body fat. Clenbuterol improved glucose tolerance after 4 days of treatment and these effects were maintained for up to 42 days. Effects were achieved with doses in a clinically relevant microgram range. Greater determination Why do people use clenbuterol? Clenbuterol’s initial use was as an asthma drug. However, bodybuilders, performance athletes, and those wanting to lose weight are now using. Clenbuterol administration caused pronounced improvements in glucose homeostasis and prevented the metabolic deficits in mouse models of β-cell dysfunction and insulin resistance. Newer research has examined clenbuterol for its potential in treating diabetes. Studies on mice have shown noticeable improvements in glucose homeostasis and prevented the metabolic deficits of beta-cell dysfunction and insulin resistance. When control and clenbuterol-treated mice were injected with an i. Glucose bolus, the clenbuterol group showed lower blood glucose levels (215 ± 15 vs. 272 ± 14 mg/dl) and a significantly greater increase in SKM levels of glucose and pyruvate (Fig. 3c) and sugars such as fructose and mannose (Fig
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